Saturday, July 26, 2008

Free Mobile download sites

Free Mobile download sites

1) FS Mobile http://www.fsmobilez.com/

2) Mobile software downloads http://www.thisismyindia.com/mobile-phones/software.html

3) Windows mobile http://www.techtree.com/techtree/jsp/list.jsp?cat=&software_type=&operating_system=Windows+Mobile&fld=Search&up1_cat_id=513&list=download_search_result&q=1

4) Symbian OS http://www.techtree.com/techtree/jsp/list.jsp?cat=&software_type=&operating_system=Symbian+Series+60&fld=Search&up1_cat_id=513&list=download_search_result&q=1

5) www.wapgautam.somee.com/wap This site contains huge database of Bollywood polytones, wallpapers, Animations, Games…etc.I wonder how he (Gautam) maintains this.

6) www.wap.sayni.net Lots of downloads, Online Image Software Nicasso allows you to make your own wallpapers, Operator logos, GIFs etc. It also provides a service called gmail-mobile. This is not official gmail, but it works almost anywhere in world on any GPRS enabled handset.

7) www.geocities.com/psychonishtarian/wapsite This too has good collection of bollywood tones, classic as well as new like Dhoom2, wallpapers, animations etc

8) www.bestpinoy.wen.ru/main.wml

9) www.tagtag.com/orkutlogin Here you can login to orkut from your mobile!

10) http://www.160by2.com/160by2_mobile_application2.aspx

10 Top in India

Mini Opera is one of the best and most widely used mobile web browser available in the market today. Their latest update has been a big hit with users. Since its worldwide launch in 2006, more than 44 million people have downloaded and used Opera Mini. More than 11.9 million people used Opera Mini in March 2008.
Opera mini has surveyed anonymous traffic of more than 44 million cumulative Opera Mini users worldwide to see where mobile users chose to spend their time when using the Web on their mobile devices. The figures released have India centric data as well, which throws up interesting numbers and sites

Number 4) http://www.peperonity.com/

Number 5) http://gallery.mobile9.com/

Number 6) http://www.mocospace.com/

Number 7) http://www.160by2.com/

Number 8) http://in.mobango.com/

Numner 9) http://www.itsmy.com/

Mobile applications

1) Wordpress For Iphone : An open source application for iPhone that lets you write posts, upload images and edit your Wordpress blog on your iPhone or iPod Touch. This application was recently launched and is hot out the oven.
2) Primospot : This service allows you to find a parking spot while you are on the go. Currently the service is available only for NY area ( Manhattan and Brooklyn ) but they plan to include Queens, Philadelphia and Boston soon. To find a parking spot you need to provide zip code, address or intersection.
3) Utterz : I personally enjoy “utters.” Utterz is a mobile application that lets you create and follow discussions with friends, family and people with similar interest. To use this service simply dial 712.432.6666 if you are in US or click here for international numbers. Once you dial the number you can record your utters or hear what others are “uttering.” Your utters can be audio, images or video.
4) Mixelpix : This service allows you to share you pictures with anyone from your computer or mobile phone. If would like to send a picture from your mobile phone , simply text your images to 817-522-8132 and share it with the world, well whoever uses this service .
5) Qik : This service recently went from private beta to public beta. Qik allows you to stream live videos directly from your cell phone to the internet. You can capture and share hours and hours of videos without ever having to worry about storage on your cell phone. Qik is pronounced as “quick.”
6) Goosync : Goosync is a service that allows you to sync your google calendar to almost any mobile device. Users have an option to either use a free account or a premium account. Premium account offers additional services and costs about 39.00 US dollars approx.
7) Digby : Digby currently is available only for Blackberry users. It allows users to find, browse and buy popular name brand products from major retailers on the internet from their cell phone. Digby’s catalog is updated daily so the blackberry users always have access to the latest product. Some of the retailers on Digby are : Best Buy, Barnes and Noble, FTD and Office Max among many others.
8) Wampad : Wampad is a search engine designed for mobile browsers. This is one of the reasons the site is so minimal. Using this search engine on your mobile browser you can pretty much search any website which includes Digg, Myspace, Del.icio.us, Flickr and many more.
9) Blueapple : Blueapple is one of the most popular mobile websites that is used to search and view any video from the internet on your mobile phone. This service allows users to search over 100 million videos on the internet from their mobile phone and share with others via SMS.
10) MapMyTracks : This application is directed towards sports enthusiasts. It allows you to accurately track and or share your sporting activity over land, sea or air. To use this service users must have a GPS enabled mobile phones.
11) Shozu : With Shozu you can take your online life with you. With the use of this application you can connect and share with most online communities from your cell phone. This app literally helps you take your online life with you no matter where you go.
12) Mofuse : Mofuse helps you launch and manage a mobile version of your blog or site. To mobilize your blog/site simply enter your URL in the box provided on the site. To use this service users do need to create an account which takes less than a minute.
13) Emoze : Emoze is a free PUSH mobile email service which eliminates the need to click on send/receive every time you want to check your email via your mobile phone. Emoze supports Gmail, Google apps, Outlook and Outlook web access making it extremely versatile and simple to use!
14) AlertU : This application provides mobile alerting for enterprises. Users can access their account from any web enabled mobile phones. Alerts are sent in the form of text messages. Account managers and individuals can send alerts in a matter of seconds which proves this service to be very efficient in case a crisis strikes.
15) Gabcast : Gabcast allows you to record podcasts using your phone. This application is very handy for podcasters on the go. In addition to recording it also allows you to publish your podcasts directly from the phone.
16) Mobiluck : Mobiluck is a free mobile tool that allows you to share your current whereabouts with your friends and family, receive alerts when one of your friends is in close proximity and chat with your IM contacts.
17) Wapedia : Are you a information junkie? If you are one of them this service will certainly make your life easier while you are on the go. Wapedia is a mobile encyclopedia for the information junkie. It houses more than 10 million articles on wikipedia so you never really have to worry about not finding something that’s on wikipedia.
18) Unwiredbuyer : This service is for people who just cant stop “ebaying.” It allows users to place last minute bids from their cell phone. Go ahead and use this service to make sure you don’t lose the product you want to other last minute bidders.
19) Buddyway : Buddy is a free GPS track maker for mobile devices that allows you to track any mobile phone or PDA with built-in GPS (or with Bluetooth GPS receiver) in real time. Use this service to keep track of your friends, share your trips, view trips in 3d in google earth and let your friends know where you are at all times.
20) Comombo : Wouldn’t it be nice to have a scanner that fits in your pocket? It certainly would. If your phone has a 2 or more mega pixel camera this free application lets you use your phone camera as a scanner.
21) Goojet : This app turns your favorite websites, web apps, RSS feeds and widgets into small pretty icons and aggregates them in one place for easy access from your mobile phone. This allows you to have all your websites and such nicely organized in a widget form on your phone called “goojets.”
22) Radio.Mundu : Allows you to access hundreds of digital internet radio stations from any web-enabled mobile phone. Browse radio by stations (or music genre) and create your favorites list. Rock on!
23) Jtwitter : A java based application that allows you to use Twitter from your phone without having to use SMS messages. We know there are many other mobile twitter apps but we wanted to include at least one. It just seems like a list is incomplete without adding one mobile twitter app .
24) Snap2Face : This app lets windows mobile users upload photos from their phone to their facebook account. It can also import your friend’s profile images to outlook contacts.
25) Metro : Metro is a small database application that allows you to download different cities metro information. A free public transportation guide on your phone.

Indian Mujahideen seems to be a pseudonym

'There is no outfit called Indian Mujahideen

With Ahmedabad blasts, we are led to the same foolish theory of Indian Mujahideen(IM). The Indian has claimed responsibility for the Jaipur blasts.
source: May 15 2008: http://www.rediff.com/news/2008/may/15rajblast9.htm

It appears to be clever ploy by the terror groups by invoking the Indian Mujahideen. So it is the third time the name of this lesser known outfit is coming to the forefront. The first time that the country heard of this outfit was during the Uttar Pradesh court blasts in November last year 2007. Then the Jaiput blasts and now the Tsunami serial blasts in Bangalore/Ahmedabad.

http://www.rediff.com/news/2008/may/15rajblast9.htm says Intelligence sources quoting as
The Indian Mujahideen is a creation of the Bangladesh-based Harkat-ul-Jihadi and the rejuvenated banned outfit SIMI.

It was during the interrogations that took place in Karnataka where seven suspected terrorists were arrested did the name Indian Mujahideen figure for the first time. These persons were questioned about the outfit and they reportedly told the police that it was a pseudonym used by SIMI activists to divert the police. It was also revealed that for every person in the force, it was mandatory to have five different names.

Essentially Indian Mujahideen seems to be a pseudonym. This is a relatively new ploy by HuJI and SIMI in order to keep their identity concealed. After the UP blasts, a mail had been sent in the name of Mohammad Shameem, claiming that the Indian Mujahideen had carried out the attack

Ahmedabad And Bangalore blasts: Analysis

In two BJP ruled states, the blasts have occured in the state capitals. In all there are around 16 blasts in Ahmedabad on Saturday July 26 2008.. Also 8 Blasts in Bangalore on Friday July 25 2008. One bomb was defused in Bangalore on Staurday morning. The similarilites are a) BJP ruled state capitals b) Local elements are suspected c) Serial Blasts in multiple places in city within a short span d) Traffic points targetted e) Done near key places, but on roadsides f) done to create panic
g) hospitals were targetted after first sequence of serial blastsThe differences a) Casualaties higher in Ahmedabad in Bangalore b) Placed in roadside scrap places in Bangalore while in Ahmedabad , tiffin boxes and cycles used c) More blasts in Ahmedabad than bangalore

Analysis of Tsunami of serial blasts in India: Ahmedabad and Bangalore

In two BJP ruled states, the blasts have occured in the state capitals. In all there are around 16 blasts in Ahmedabad on Saturday July 26 2008.. Also 8 Blasts in Bangalore on Friday July 25 2008. One bomb was defused in Bangalore on Staurday morning.

The similarilites are
a) BJP ruled state capitals
b) Local elements are suspected
c) Serial Blasts in multiple places in city within a short span
d) Traffic points targetted
e) Done near key places, but on roadsides
f) done to create panic
g) hospitals were targetted after first sequence of serial blasts

The differences
a) Casualaties higher in Ahmedabad in Bangalore
b) Placed in roadside scrap places in Bangalore while in Ahmedabad , tiffin boxes and cycles used
c) More blasts in Ahmedabad than bangalore

Subhiksha godowns to be inspected over hygiene complaints

The food hygiene if not maintained by retail companies like Subhiksha, then the future of food hygiene needs to be looked gravely. Is there not a need to look into licensing for all retail stores so that the consumer interest is safeguarded. There is also a notion that retail companies need to improve their quality standards.

http://www.hindu.com/thehindu/holnus/002200807261859.htm
Mumbai (PTI): The Maharashtra government on Saturday announced that it would recheck godowns of 'Subhiksha' store chain following complaints of violation of hygiene norms.
Deputy Chairman of the Legislative Council Vasant Davkhare asked the government to recheck the godowns of Subhiksha store and cancel the licence if norms were violated.
Taking note of the directives given by Davkhare, Minister of State for Food and Drug Administration Baba Siddiqui assured to recheck the godowns.
He said instructions would be given to FDA Commissioner for the rechecking.
The licence of the store was cancelled from March 1 to March 10 and from June 23 to June 27 for not maintaining proper hygiene in the food packaging area, Siddiqui said.
The issue was raised by Leader of the Opposition Pandurang Phundkar, who asked the government to cancel the licence for a few more days.
Phundkar said despite 'Subhiksha' not having the repacking licence, the store was found doing so.
As per the report prepared by the FDA during earlier checking, food was found lying on floor amid spit and dust, Phundkar said. This posed danger to public health and the licence of the store should be cancelled by the Government, he said.

13 Blasts in Ahmedabad after Bangalore

What is going on in this country? Why are so many cities facing serial blasts that too one after another. I am not from ahmedabad but I share the feeling of the bad people of the loss of lives and panic caused. This Week is indeed a black week.

We as Indians will remain resolute and fight back with our calmness. The terrorists will be definitrly caught.

Source:http://www.ndtv.com/convergence/ndtv/story.aspx?id=NEWEN20080058856
13 blasts rock Ahmedabad, 2 killed

Thirteen blasts have rocked Ahmedabad killing 2 and injuring at least 20 people on Saturday evening.The first blast took place in Bapunagar at 6:45 pm and all the blasts took place within a span of 15 minutes.The blasts took place in Maninagar, Sarkhej, Isanpur, Bapunagar and Haksar. Maninagar being Gujarrat CM Narendra Modi's constituency.The bombs were planted on cycles in crowded marketplaces and tiffin boxes.Police have rushed to the affected spot and there is no confirmation on the kind of explosion.The blasts have taken place primarily in eastern part of Ahmedabad, which are upper middle class dominated areas.Security agencies have been put on high alert and mobile phones blocked.They are trying to figure if more bombs are there like in the case of Bangalore blasts. These blasts take place exactly a day after eight low intensity serial blasts in Bangalore.Prime Minister Manmohan Singh and President Pratibha Patil have condemned the serial blasts.

Friday, July 25, 2008

Harmony® 885 Advanced Universal Remote

Cnet review says it is a true vinversal remote. Cnet says it is the best as per
http://reviews.cnet.com/best-universal-remotes/








Command
One trigger finger is all you need.
One-Touch Control: Choose the activity you want to do, not the component you want to turn on.
Up to 15 Components: Control video, audio, gaming—even lights and appliances.
Customizable Buttons: Put your most frequent activities at your fingertips.
Learning Port: Add favorite functions from an old remote just by pointing it at your Harmony.





Comfort and Convenience
Never get numb-thumb again.
Charging Station: Put your remote in its own home and forget about changing batteries.
Comfort-Grip Shape: Hold on comfortably and reach all the buttons with ease.
Fully Backlit Controls and LCD Display: Navigate even in movie-theater darkness.
Help Button: Confused? Let the Help Button figure it out for you. (No one else has one.)





Simple Setup
It doesn’t get easier than this.
Online Wizard: Plug into a USB port and walk right through initial setup or adding equipment.
Incredible Compatibility: From laser disc to Blu-Ray® disc, find your components in our 175,000-device database.
Free Support: Expect total customer satisfaction, whether you have a problem or just a question.


Cnet review comment:
http://reviews.cnet.com/Logitech_Harmony_One/4864-7900_7-32825878.html?messageID=2557205
This is my first true Universal Remote, and I must say that I am impressed so far.

Initial programming was a very straightforward process for me. The software asks simple questions not only about your gear, but also how they interact with one another for each specific activity. The only caveat is you MUST know how your gear is connected, i.e. the dvd player is connected to the dvd input or component 1 input.

Initial programming and testing took me about an hour and a half, only because the remote was having trouble switching source inputs on my tv and couldn't figure out how to turn on power to the XBox. A troubleshooting section in the software was able to remedy both issues though.

All the labels are customizable, which helps when you have multiple devices that play video (DVD, XBox, PS3, AppleTV). (The PS3 does not have an IR sensor, so Harmony Remotes are useless for PS3 function. I do have complete control of my AppleTV, however.)

The Activities are completely under your control as well. You can create whatever activity you want by answering a few simple questions about your devices and the software makes all the changes.

The touchscreen function is phenomenal! All of your activities are located on the screen and with the touch of soft button, you can powerdown your dvd player, turn the satellite box on, change the input on the tv and receiver and your golden. The most common functions for the current activity are located on physical buttons beneath the touchscreen, so there is very little hand sliding up and down the remote looking for the volume and channel buttons. The button layout is also a plus.

One of the best features is the onscreen Remote Assistant. If watching a dvd causes you to perform multiple functions and the tv doesn't change to the proper input, pressing the Help key does exactly that, it helps. The remote asks you simple questions, Is the tv on?, Is the DVD player on?, and so on until it finds a device not set properly based on your input. It will then resend that command to the device until the setting is correct. This is extremely beneficial when your tech terrified girlfriend calls you at work because she can't get General Hospital on tv, or she can see it but can't hear it.

I've been using the remote for a couple of days and I am very pleased so far. The girlfriend likes it as well, which makes life easier all the way around for me.

Now the bad: The glossy finish shows fingerprints and smudges way to easily. It comes with a micro fiber cloth to wipe it down, but I have found myself wiping it alot.

Touchscreen is way too sensitive out of the box. A very light brush across the screen was activating several functions. Fortunately though, there is a sensitivity setting that you can manipulate (Once you find it, that is).

I have also noticed that my girlfriend had to use two hands at times. She has small hands and was holding it near the touchscreen while entering channel numbers which are near the bottom. She has also had to use two hands when using the touchscreen. It's not a deal breaker, but maybe something to consider for some buyers.

SMB- accounting software- SAP B1 and SAP A1FS

The ideal accounting software better than SAGE and Quicken with integration features is SAP B1. B1 is VB base and for generic industries, the license cost is 4-6 Lakhs for 10 users and implementation from 2-3 Lakhs. SO total within 10 Lakhs, you get a good software

Another option is to go for SAP A1FS with license costs from 13-15Lakhs. And implementationa round 10Lakhs comes to total costs around 25 Lakhs. A1Fs packs teh best practices for India. So far it is released only for India. The releases for A1FS are in trading, manufacturing and services.
The RoI for trading is recognized instantly.
www.sap.com

Isabgol - The Colon cleanser

The experimental growth of the crop in Bangalore has been proven
http://www.indg.in/agriculture/crop_production_techniques/medicinalcrops/isabgol/view?set_language=te

http://nutrihealth.in/2008/06/isabgol-the-colon-cleanser/
Isabgol (psyllium husks) a natural vegetable product in highly purified form is nature’s highest soluble fibre obtained from plantago ovata (Isabgol) seeds.It is a naturally healthy fibre and is not absorbed in the intestine. It has no known interaction with other drugs, and does not interfere with the absorption of vitamin and minerals.
This product is mainly used as a bowel regulator.Isabgol absorbs water and swells up to give increased bulk in the intestine. The fiber present in Isabgol is soluble in nature. This fiber is different from the other type of fibers such as wheat bran and cellulose, which are insoluble. Isabgol is recommended for relief of problems associated with chronic constipation such as piles, fissures and fistulas. Isabgol helps to moisten the hard stools and brings down the burning sensation after defecation. It helps to reduce strain during defecation in persons suffering from cardio vascular diseases, hernia and pregnancy. It also increases the moisture content of the stools. This promotes the normal peristaltic movements and the bowel mobility.The fiber present in Isabgol helps to control the blood cholesterol levels. Isabgol also helps to prevent heart attacks by regulating the serum cholesterol. Isabgol forms a thin layer on the intestines and prevents the absorption of cholesterol in to the arteries. Thus the cholesterol levels in the body is maintained. It also helps to regulate the blood glucose levels and insulin response by decreasing the absorption of fats and glucose. Isabgol also helps to clean the gastro intestinal tract by removing the toxins present there along with the bulk. Thus the toxins are excreted from the body. Isabgol also helps to prevent indigestion, and flatulence. It removes any material, which may cause intestinal obstruction. Isabgol helps to prevent lethargy and gives a feeling of well being and good health. Isabgol forms a bulk on swelling, it is classified as a bulk-laxative. It is usually effective within 8-12 hours.Isabgol should be stirred in a full glass of fluid such as water or juice, just before ingestion. Failure to consume sufficient fluid with a bulk laxative decreases its efficacy. Intake of the husk without fluids should be strictly avoided. Consumed with water prior to meals, reduces consumption of fat and calories. Recommended to supplement fibre deficient diet may be used 5 to 10 grams daily with a glass of water , syrup, milk, fruit-juice, salted curd or lassi. The Dosage can go up to three times a day as per individual requirements and One teaspoon daily at bedtime is also advised.

Randy Pausch : The Lessons I'm Leaving Behind

Though he died of pancreatic cancer, his story will be online . I also share his thoughts

"I could put myself in a bottle that would one day wash up on the beach for my children"

The story of Randy Pausch must be retold: excerpts from Last lecture

Randy Pausch, a Carnegie Mellon University professor whose "last lecture" about facing terminal cancer became an Internet sensation, has died. He was 47. Pausch wrote the following story about his experiences for PARADE magazine. It originally appeared in the April 6, 2008 issue.
Watch Randy Pausch's Last LectureAt many colleges, professors are asked to give a “last lecture.” In this talk, they ruminate on what matters most to them. As they speak, audiences mull the same question: What wisdom would you impart to the world if you knew it was your last chance? Last year, I agreed to give a last lecture at Carnegie Mellon University, where I’m a professor in the computer science department. A few weeks later, I learned that I had only months to live—I was dying of pancreatic cancer. I knew I could cancel. I have three young children, I’m married to Jai, the woman of my dreams, and there were so many things to be done. But by speaking, I knew I could put myself in a bottle that would one day wash up on the beach for my children, Dylan, Logan and Chloe. Here’s what I want to share.
Always Have FunBefore I spoke, Carnegie Mellon’s president, Jared Cohon, said to me, “Please tell them about having fun, because that’s what I’ll remember you for.”I came to an early realization. Each of us must make a decision, best captured in A.A. Milne’s Winnie-the-Pooh characters. Am I a fun-loving Tigger or a sad-sack Eeyore? It’s clear where I stand.For my last Halloween, Jai, our kids and I dressed up as the Incredibles. I put a photo of us on my website and explained that chemo had not affected my superpowers. I got smiling e-mails in response.I won’t let go of the Tigger in me. Someone asked what I want on my tombstone. I said: “Randy Pausch: He Lived 30 Years After a Terminal Diagnosis.” I could pack a lot of fun into 30 years. If that’s not to be, I’ll pack fun into the time I have.
Dream Big I was 8 in the summer of 1969, when men first walked on the moon. I was at camp, and we campers were brought to the main house to watch the moment on TV. But the astronauts were taking a while, and it was late. The counselors sent us to our tents to sleep, and we missed the first walk.I was peeved. I thought: “My species has gotten off our planet and is in a new world for the first time, and you people think bedtime matters?”When I got home, my dad gave me a photo that he’d taken of our TV set the second Neil Armstrong set foot on the moon. We still have that photo. Give yourself permission to dream. Fuel your kids’ dreams too. Once in a while, that might even mean letting them stay up past their bedtimes.
Ask for What You Want On a trip to Disney World, my dad and I were at the monorail with my son Dylan, then 4. Dylan wanted to sit in the nose-cone with the driver, and my father thought it would be a kick too.“Too bad they don’t let regular people sit there,” Dad said. “Actually, I’ve learned there’s a trick to getting to sit up front,” I said. “Do you want to see it?” I walked over to the attendant and said: “Excuse me. Could we please sit in the front car?”“Certainly,” the attendant said. He led us to the nose-cone. It was one of the only times I ever saw my dad flabbergasted. “I said there was a trick,” I told him. “I didn’t say it was a hard trick.”Now I’ve gotten even better at “just asking.” As we all know, it can take days to get medical results. Waiting is not how I want to spend my time, so I ask: “What’s the fastest I can get these results?”“Oh,” they often respond, “we might be able to have them for you within an hour.”Ask. More often than you’d suspect, the answer you’ll get is, “Sure.”
Dare To Take a RiskIn a virtual-reality course I taught, I encouraged students to attempt hard things and not worry about failing. At the end of the semester, I presented a stuffed penguin—“The First Penguin Award”—to the team that took the biggest gamble while not meeting its goals. The award came from the idea that when penguins jump in water that might have predators, well, one of them’s got to be the first penguin. In essence, it was a prize for “glorious failure.”Experience is what you get when you don’t get what you wanted. And it can be the most valuable thing you have to offer.
Look for the Best In EverybodyI got this advice from Jon Snoddy, my hero at Disney Imagineering. “If you wait long enough,” he said, “people will surprise and impress you.” When you’re frustrated with people, when you’re angry, it may be because you haven’t given them enough time. Jon warned that this took great patience, even years. “In the end,” he said, “people will show you their good side. Just keep waiting. It will come out.”
Make Time for What MattersWhen Jai and I went on our honeymoon, we wanted to be left alone. Since my boss demanded a way for people to reach me, I recorded this greeting: “Hi, this is Randy. I waited until I was 39 to get married, so my wife and I are going away for a month. I hope you don’t have a problem with that, but my boss does. Apparently, I have to be reachable.” I then gave the names of Jai’s parents and the city where they lived. “If you call directory assistance, you can get their phone number. And then, if you can convince my in-laws that your emergency merits interrupting their only daughter’s honeymoon, they have our number.” We didn’t get any calls.Time is all you have. And you may find one day that you have less than you think.
Let Kids Be Themselves Because I’ve been so vocal about my childhood dreams, people have asked me about the dreams I have for my own kids. As a professor, I’ve seen how disruptive it can be for parents to have specific dreams for their children. My job is to help my kids foster a joy for life and develop the tools to fulfill their own wishes. My wishes for them are very exact and, given that I won’t be there, I want to be clear: Kids, don’t try to figure out what I wanted you to become. I want you to become what you want to become. And I want you to feel as if I am there with you, whatever path you choose.Adapted from the book The Last Lecture, by Randy Pausch and Wall Street Journal reporter Jeffrey Zaslow. Copyright © 2008 Randy Pausch. To be published by Hyperion. All rights reserved.AFTER THE LECTUREAfter I gave my lecture in September, I expected to go home and quietly spend time with my family. I never imagined that my talk would be viewed online by millions worldwide. The response has overwhelmed and moved me. Thousands of people have written to me about their life lessons. I’ve also been buoyed by former students who’ve told me how my teaching made a difference to them. There’s no greater gift for a teacher. I’ve used my unexpected fame to advocate for pancreatic cancer research. Last month, I testified before Congress to seek funding for my disease, which is considered the deadliest of cancers. I’ve had great fun too. In my lecture, I told of two childhood dreams: playing in the NFL and being Captain Kirk on Star Trek. Strangers fulfilled those wishes. I was invited to scrimmage with the Pittsburgh Steelers and got to say a line in a new Star Trek film. Both experiences were thrilling.I’m lucky to be living longer than I expected, allowing me more time with my kids. I’ve tried to do unforgettable things with them—such as swimming with dolphins—so they’ll have concrete memories of us and of my love for them. I am honored that my lecture will live on and that people have found it beneficial. Honestly, though, the talk was for my kids, and it gives me comfort to know that they will one day watch it.

Escaped 'spam king' Edward "Eddie" Davidson allegedly kills self, family

http://news.cnet.com/8301-1009_3-9999451-83.html?part=rss&subj=news
A convicted spammer who escaped from prison was found dead Thursday night, along with his wife and 3-year-old daughter.

Eddie Davidson, dubbed a "spam king," was sentenced to 21 months in prison in April after pleading guilty to falsifying header information to send spam e-mail, tax evasion, and criminal forfeiture, the Associated Press reported.

Police had been searching for Davidson since Sunday, when he escaped from a minimum-security federal prison in Florence, Colo., 90 miles south of Denver, according to the AP.

Police responding to reports of gunshots found Davidson and his family in an SUV in a driveway in Bennett, Colo., according to news reports. A baby was found in a car seat uninjured, and a teenage girl who was shot in the neck ran to a neighbor's house for help and has been hospitalized. The relationship of the baby and teen to Davidson is unclear, according to the AP.

Earlier,
Less than two months into his 21-month prison sentence, convicted spammer Edward "Eddie" Davidson, 35, decided he'd had enough and, according to the U.S. Attorney's Office in Colorado, "walked away" from the minimum-security prison in Florence, Colo., where he was being held.
Davidson forced his visiting wife to help him escape, the Rocky Mountain News reported. After returning to his wife's home in Lakewood, Colo., for a change of clothes, he was last seen leaving in her 2006 silver Toyota (NYSE: TM) Sequoia.

http://www.informationweek.com/news/internet/security/showArticle.jhtml?articleID=209600539

Stop ageing using H2S - 'Hibernation-on-demand'




'Hibernation-on-demand' drug significantly improves survival after extreme blood loss .Science could halt or reverse ageing. Scientists from Stanford University argue regulatory genes could determine when a body begins to break down, rather than the conventional view that ageing is caused by wear and tear.
Should they prove correct, future research may find a way of turning off the signals emanating from the genetic instructions thereby halting the sign of ageing.
Marc Tatar, from Brown University in Rhode Island said: "The message of this research is that ageing can be slowed and managed by manipulating signalling circuits within cells."
The researchers used examples of tortoises able to lay their eggs aged 100 or whales living until 200, despite the fact they use the same building blocks for their DNA, proteins and fats as humans, mice and nematode worms.
The chemistry of the wear-and-tear process should therefore be the same in all cells, which makes it difficult to explain why species have different life spans.
Studying the nematode worm, one of the most primitive living creatures, a millimetre long, with a maximum life span of two weeks, they found differences between young and old worms that did not match the conventional picture of ageing.
They were exposed to different stresses, thought to cause ageing, such as heat, radiation and disease but found the genes were not affected.
Instead key genetic mechanisms designed for youth had drifted off track in older animals.
One of the researchers, Professor Stuart Kim, a professor of developmental biology, said: "We found a normal developmental programme that works in young animals, but becomes unbalanced as the worm gets older.
"It accounts for the lion's share of molecular differences between young and old worms."
source: http://www.telegraph.co.uk/news/2457653/Science-could-halt-or-reverse-ageing.html

Low doses of the toxic gas responsible for the unpleasant odor of rotten eggs can safely and reversibly depress both metabolism and aspects of cardiovascular function in mice, producing a suspended-animation-like state. In the April 2008 issue of the journal Anesthesiology, Massachusetts General Hospital (MGH) reseachers report that effects seen in earlier studies of hydrogen sulfide do not depend on a reduction in body temperature and include a substantial decrease in heart rate without a drop in blood pressure.
“Hydrogen sulfide is the stinky gas that can kill workers who encounter it in sewers; but when adminstered to mice in small, controlled doses, within minutes it produces what appears to be totally reversible metabolic suppression,” says Warren Zapol, MD, chief of Anesthesia and Critical Care at MGH and senior author of the Anesthesiology study. “This is as close to instant suspended animation as you can get, and the preservation of cardiac contraction, blood pressure and organ perfusion is remarkable.”
Previous investigations into the effects of low-dose hydrogen sulfide showed that the gas could lower body temperature and metabolic rate and also improved survival of mice whose oxygen supply had been restricted. But since hypothermia itself cuts metabolic needs, it was unclear whether the reduced body temperature was responsible for the other observed effects. The current study was designed to investigate both that question and the effects of hydrogen sulfide inhalation on the cardiovascular system.
The researchers measured factors such as heart rate, blood pressure, body temperature, respiration and physical activity in normal mice exposed to low-dose (80 ppm) hydrogen sulfide for several hours. They analyzed cardiac function with electrocardiograms and echocardiography and measured blood gas levels. While some mice were studied at room temperature, others were kept in a warm environment – about 98º F – to prevent their body temperatures from dropping.
In all the mice, metabolic measurements such as consumption of oxygen and production of carbon dioxide dropped in as little as 10 minutes after they began inhaling hydrogen sulfide, remained low as long as the gas was administered, and returned to normal within 30 minutes of the resumption of a normal air supply. The animals’ heart rate dropped nearly 50 percent during hydrogen sulfide adminstration, but there was no significant change in blood pressure or the strength of the heart beat. While respiration rate also decreased, there were no changes in blood oxygen levels, suggesting that vital organs were not at risk of oxygen starvation.
The mice kept at room temperature had the same drop in body temperature seen in earlier studies, but those in the warm environment maintained normal body temperatures. The same metabolic and cardiovascular changes were seen in both groups, indicating that they did not depend on the reduced body temperature, and analyzing the timing of those changes showed that metabolic reduction actually began before body temperature dropped.
“Producing a reversible hypometabolic state could allow organ function to be preserved when oxygen supply is limited, such as after a traumatic injury,” says Gian Paolo Volpato, MD, MGH Anesthesiology research fellow and lead author of the study. “We don’t know yet if these results will be transferable to humans, so our next step will be to study the use of hydrogen sulfide in larger mammals.”
Zapol adds, “It could be that inhaled hydrogen sulfide will only be useful in small animals and we’ll need to use intravenous drugs that can deliver hydrogen sulfide to vital organs to prevent lung toxicity in larger animals.” Zapol is the Reginald Jenney Professor of Anaesthesia at Harvard Medical School.



With an incredible lifespan of up to 250 years, the deep-sea tube worm, Lamellibrachia luymesi, is among the longest-lived of all animals, but how it obtains sufficient nutrients -- in the form of sulfide -- to keep going for this long has been a mystery. In a paper just published in the online journal PLoS Biology, a team of biologists now provide a solution: by releasing its waste sulfate not up into the ocean but down into the sediments, L. luymesi stimulates the growth of sulfide-producing microbes, thus ensuring its own long-term survival.
The research team includes Erik E. Cordes, a postdoctoral researcher in the laboratory of Charles Fisher, professor of biology at Penn State, along with Katriona Shea, assistant professor of biology at Penn State, Michael A. Arthur, a professor of geosciences at Penn State, and Rolf S. Arvidson, an earth sciences research scientist at Rice University.
The sulfide this worm needs is created by a consortium of bacteria and archaea that live in the cold deep-sea sediments surrounding the seep where the worm lives. These organisms use energy from hydrocarbons to reduce sulfate to sulfide, which L. luymesi absorbs through unique root-like extensions of its body, which tunnel into the sediments. However, current measurements of sulfide and sulfate fluxes in the water near the vents do not match either the observed size of the tubeworm colony or the observed longevity of its individuals, leading Cordes et al. to propose that L. luymesi also uses its roots to release sulfate back to the microbial consortia from which it draws its sulfide. Without this return of sulfate, the model predicts an average lifespan of only 39 years in a colony of 1,000 individuals; with it, survival increases to over 250 years, matching the longevity of actual living tubeworms.
To date, the proposed return of sulfate to the sediments through the roots is only a hypothesis -- albeit one with much to support it -- that still awaits direct confirmation. By providing a model in which this hypothetical interaction provides real benefits and explains real observations, the authors hope to stimulate further research into the biology of the enigmatic and beautiful L. luymesi.
This research was supported by the National Science Foundation.



Scientists at Fred Hutchinson Cancer Research Center have, for the first time, induced a state of reversible metabolic hibernation in mice. This achievement, the first demonstration of "hibernation on demand" in a mammal, ultimately could lead to new ways to treat cancer and prevent injury and death from insufficient blood supply to organs and tissues.
"We are, in essence, temporarily converting mice from warm-blooded to cold-blooded creatures, which is exactly the same thing that happens naturally when mammals hibernate," said lead investigator Mark Roth, Ph.D., whose findings will be published in the April 22 issue of Science.
"We think this may be a latent ability that all mammals have -- potentially even humans -- and we're just harnessing it and turning it on and off, inducing a state of hibernation on demand," said Roth, a member of Fred Hutchinson's Basic Sciences Division.
During a hibernation-like state, cellular activity slows to a near standstill, which reduces dramatically an organism's need for oxygen. If such temporary metabolic inactivity — and subsequent freedom from oxygen dependence — could be replicated in humans, it could help buy time for critically ill patients on organ-transplant lists and in operating rooms, ERs and battlefields, Roth said.
"Manipulating this metabolic mechanism for clinical benefit potentially could revolutionize treatment for a host of human ills related to ischemia, or damage to living tissue from lack of oxygen," said Roth, also an affiliate professor of biochemistry at the University of Washington School of Medicine.
Collaborators on the research included first author Eric Blackstone, a graduate research assistant in Roth's laboratory and a member of the joint Fred Hutchinson/University of Washington Molecular and Cellular Biology Program; and co-author Mike Morrison, Ph.D., a staff scientist in Roth's lab.
Clinical applications of induced metabolic hibernation could include treating severe blood-loss injury, hypothermia, malignant fever, cardiac arrest and stroke.
The potential medical benefits also include improving cancer treatment by allowing patients to tolerate higher radiation doses without damaging healthy tissue. Cancer cells, Roth explained, aren't dependent on oxygen to grow. As a result, they are more resistant to radiation than surrounding healthy cells, which need oxygen to live. Roth hypothesizes that temporarily eliminating oxygen dependence in healthy cells could make them a less-vulnerable target for radiation and chemotherapy and thus spare normal tissue during high-dose cancer therapy.
"Right now in most forms of cancer treatment we're killing off the normal cells long before we're killing off the tumor cells. By inducing metabolic hibernation in healthy tissue we'd at least level the playing field," he said. The delivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with trace amounts of an agent that would interfere with the body's ability to use oxygen, Roth said.
Using oxygen deprivation to depress metabolic activity also might extend the amount of time that organs and tissues could be preserved outside the body prior to transplantation, Roth said. Yet another potential application of oxygen deprivation would include accelerating wound healing in patients, such as diabetics, whose ability to do so is compromised. This could reduce the number of amputations caused by irreparable tissue damage from wounds that won't heal. A wound to the skin allows the entry of oxygen, which initiates cell death. In healthy people, cell death subsides when a clot forms, which allows the healing process to begin. Exposing a diabetic's clot-resistant wound to an oxygen-free environment would speed the healing process.
While the notion of putting a human or a human organ into an oxygen-free state of biological limbo and then reversing the process at will with no ill effects may sound like science fiction, dozens of documented cases exist of humans surviving prolonged hibernation-like states with no lingering physical or neurological damage. For example:
* In May 1999, a female Norwegian skier was rescued after submersion in icy water for more than an hour. When rescued she was clinically dead with no heartbeat, no respiration, and her body temperature had fallen to 57 degrees Fahrenheit (normal is 98.6 F). She was resuscitated and since has made a good physical and mental recovery.
* More recently, in February 2001, Canadian toddler Erika Nordby made headlines around the world — and a complete recovery — after she wandered outside at night and nearly froze to death. Before she was resuscitated her heart had stopped beating for two hours and her temperature had plunged to 61 F.
"Understanding the connections between random instances of seemingly miraculous, unexplained survival in so-called clinically dead humans and our ability to induce — and reverse — metabolic quiescence in model organisms could have dramatic implications for medical care," Roth said. "In the end I suspect there will be clinical benefits and it will change the way medicine is practiced, because we will, in short, be able to buy patients time."
In the Science paper, Roth and colleagues report inducing a state of clinical torpor in mice for up to six hours before restoring their normal metabolic function and activity.
They achieved this by placing the mice in a chamber filled with normal room air laced with 80 parts per million of hydrogen sulfide, a chemical normally produced in humans and animals that is believed to help regulate body temperature and metabolic activity.
Within minutes of breathing the hydrogen sulfide and room-air cocktail, the mice stopped moving and appeared to lose consciousness, their respiration dropped from the normal 120 breaths per minute to fewer than 10 breaths per minute, and their core temperature dropped from the normal 37 degrees Celsius to as low as 11 C, depending on the controlled ambient temperature within the chamber.
"We have, on demand, reversibly demonstrated the widest range of metabolic flexibility that anyone has ever seen in a non-hibernating animal," Roth said.
"The cool thing about this gas we're using, hydrogen sulfide, is that it isn't something manufactured that we're taking down from a shelf — it isn't 'better living through chemistry' — it's simply an agent that all of us make in our bodies all the time to buffer our metabolic flexibility. It's what allows our core temperature to stay at 98.6 degrees, regardless of whether we're in Alaska or Tahiti," Roth said.
In addition to mice, Roth and colleagues in previously published work have demonstrated the ability to metabolically arrest — and subsequently re-animate — such model organisms as yeast and worms, as well as the embryos of fruit flies and zebrafish.
In each case they achieved metabolic suspension through oxygen deprivation caused by exposure to gases such as hydrogen sulfide and carbon monoxide. Known as oxygen mimetics, these chemicals are very similar to oxygen at the molecular level and so bind to many of the same receptor sites. As a result, they compete for and interfere with the body's ability to use oxygen for energy production - a process within the cell's power-generating machinery called oxidative phosphorylation. The inhibition of this function, in turn, is what the researchers believe causes the organism to shut down metabolically and enter a hibernation-like state. In each case, upon re-exposure to normal room air, the organisms quickly regained normal function and metabolic activity with no long-term negative effects.
If Roth and colleagues are able to replicate these findings in larger animal models, they foresee the first clinical use of this technology in humans could involve treating people suffering from severe fevers of unknown origin. Currently, when a person comes to an ER with such a fever they run the risk of brain-damaging seizures during the crucial time it takes to diagnose the bacterial or viral cause and administer the proper antibiotic.
"Here's a patient group, quite commonly found in emergency rooms around the country, who would do well if they could just have their core body temperature taken down in order to buy them time until the pathology reports come back and they can get on the right course of treatment," Roth said. "Today, physicians have no way of dealing with uncontrolled fever other than literally putting people on ice. Well, we believe we know how to flip the breaker on the patient's furnace; if they have a fever, we believe we know how to stop it on a dime." Roth anticipates that such clinical trials in humans could be under way within about five years.
The National Institutes of Health and Fred Hutchinson Cancer Research Center funded this research.



For the first time, researchers have demonstrated that the administration of minute amounts of inhaled or intravenous hydrogen sulfide, or H2S – the molecule that gives rotten eggs their sulfurous stench – significantly improves survival from extreme blood loss in rats.

Cell biologist Mark B. Roth, Ph.D., and colleagues in the Basic Sciences Division of Fred Hutchinson Cancer Research Center, in collaboration with surgeon Robert K. Winn, Ph.D., and colleagues at UW Medicine's Harborview Medical Center, report their findings online ahead of print in The Journal of Trauma Injury, Infection, and Critical Care. The article is slated for the July print issue, which comes out on July 10.

The researchers successfully used H2S to induce a state of reversible metabolic hibernation as a way to reduce death from insufficient blood supply to organs and tissues in a rat model of lethal hemorrhage. (Federal regulations mandate the use of such animal models in preclinical research to test the safety and effectiveness of various procedures and treatments before they can be tested in humans.)

They found that 75 percent of rats (18 of 24) given inhaled hydrogen sulfide and 67 percent of rats (eight of 12) given intravenous hydrogen sulfide survived at least two weeks – the duration of the monitoring period – after losing more than half of their blood for an extended period. In contrast, long-term survival rates for the untreated rats in the two control groups were 23 percent (three of 13) and 14 percent (one of seven), respectively.

"Our goal is to develop life-saving treatment for critically ill people suffering from acute, sustained blood loss, such as in a car accident or on the battlefield," said senior author Roth. "These findings have obvious implications for the military, but they also have tremendous implications for the civilian population."

The U.S. Defense Advanced Research Projects Agency and the U.S. Defense Services Office funded the research. The ultimate goal: designing self-injectable hydrogen-sulfide kits that critically injured soldiers could use in the field to temporarily dim their metabolism and reduce their oxygen demand. This would help "buy time" until they could get medical attention.

"The military feels that if a soldier can be kept alive for at least three hours, that would allow time for the situation to be stabilized and the scene of the incident secured enough to allow evacuation of that soldier to an area where he or she can get medical attention," Roth said.

Roth's study, which attempted to mimic a similar scenario, involved 56 rats, each of which underwent controlled hemorrhage to remove 60 percent of their blood for three hours before re-infusion with Lactated Ringer's solution to replace lost blood volume.

The rats were divided into two groups. In the first group, 24 rats were put into a controlled atmosphere of room air laced with 300 parts per million H2S while 13 served as controls. The H2S was administered about 20 minutes after initiation of blood removal and was supplied for about 20 minutes, until the end of the bleed. In the second group, 12 rats received a single intravenous dose of sulfide solution about 20 minutes after the initiation of blood removal while seven served as controls.

In both test groups, the rats maintained a reduced yet stable level of carbon-dioxide production, a surrogate measure of metabolism. Once H2S was removed, metabolic rates returned to normal. In contrast, the untreated animals steadily grew metabolically weaker from blood loss until the point of death.

Functional and behavioral testing among the long-term survivors (those that lived more than two weeks after hemorrhage) showed no observable defects. In fact, the rodents that were bred produced normal-sized litters of healthy pups.

How does hydrogen-sulfide treatment prevent death from profound and sustained blood loss? One possibility is that in reducing metabolism, H2S also reduces oxygen demand, which allows crucial neurons in the hippocampus, the part of the brain that controls autonomic functions such as breathing and heartbeat, to withstand low oxygen levels due to hemorrhage.

Another mechanism may be that hydrogen sulfide, which is naturally present in the blood, is lost during hemorrhage and must be replaced to maintain life processes.

In April 2005 Roth and colleagues made headlines worldwide when they reported, in the journal Science, the first use of H2S to induce a state of reversible hibernation in mice. Roth's latest research represents the next step in demonstrating hydrogen sulfide's potential to treat ischemic injuries caused by conditions such as severe blood loss, hypothermia, cardiac arrest and stroke.

160by2 : Free SMS when you have network problems


160by2 is a perfect way to sms for free. When bangalore blasts, the telephone networks went down. 160by2 was a way to communicate. With more than 7 crore smses and 1 million base 160by2 has the possibility for immense growth.


Send free SMS to any mobile in India Sign Up to get started -->>
Over 7 Crores SMS sent
Ranked 78th Most Popular Website in India (source: alexa)
Ranked 7th Most Popular WAP site in India (source: opera)
Over 15 lakh Registered Users

Also access 160by2 from
Email - You can send free SMS from ur email.
Know more >>
Mobile - Visit 160by2 from your mobile at http://m.160by2.com
Mobile Application - Download our mobile application to send FREE SMS. Also Backup your address book. Know more >>
Blog - Increase traffic and retain loyalty with our widget on your blog / website. Know more >>




India's leading Online Free SMS service recently crossed the 1 million users landmark. Now with 1.4 million users, the company is planning a slew of features that would provide more utility to its users as well as help in increasing user base.
SMS Country Networks last week launched a redesigned home page of their Free SMS portal, 160by2.com. The move is in accordance to the company's focus on expanding the user base by educating their visitors about the different channels through which they could send free SMSes. 160by2.com, part of SMS Country Networks, which also owns SMSCountry.com (a leading bulk SMS service), had also recently crossed the 1 million users landmark.
The website which ranks as the 76th most popular in India according to Alexa also ranks as the seventh most popular WAP site in India according to a recent survey by Opera. According to Mr. Satya Yerramsetti, the CEO of SMS Country Networks, 'The popularity of the website indicates a growing trend of mobile and internet converging across the globe, especially in India. This also provides us an opportunity to serve our users through a free service that is a culmination of the mobile and internet'. 160by2.com lets its users to send free SMSes anywhere in India. The service generates revenue from advertisers who market their products to a contextually and geographically targeted audience. The concept has been a hit among the advertisers of 160by2 which now boasts of a clientele that includes Cadbury, Coca Cola, Jet Airways, Kingfisher, Kotak, Moneyline, Start TV and Zee network among others.
According to Mr. Satya, 'The redesigned homepage of 160by2.com is cleaner and focuses on letting our users know of the channels, apart from the website, from where they could avail the free SMS service of 160by2'. The new features launched in the past few months include a WAP alternative of 160by2.com, an Email to SMS feature, a mobile application and also a widget that bloggers and website owners may incorporate on their sites to let their readers send free SMS through the 160by2.com gateway.
These new features have helped the company with a prolific growth rate in the past few months. The widget has also become popular with a vast number of blogs using the application on their blogs. Another feature to have taken off really well is the Email to SMS feature which lets the users send SMS to their friends from their email. According to Mr. Satya, 'The Email to SMS feature was specifically conceptualized for the office goers who have access to their office mailboxes, but are denied internet at work. We saw a gap here which could be filled with an Email to SMS feature. As anticipated, this feature has been received really well from our users and we have received tremendous positive feedback'.
The site has been focusing on providing more value to its users. Among other things, the website also offers birthday and anniversary alerts, and reminders on SMS. One of the most popular features on the website is contacts back up feature, wherein users can back up their mobile phone contacts online. The users can download and upload contacts in simple excel format. In the unfortunate event of user losing the phone, she can always retrieve her contacts from 160by2.
The service is planning a slew of features that shall be launched in next three months. The objective of the team is to develop 160by2 as the leading internet-mobile convergence service in India, where digital media merges in true sense. 160by2 has more than 1.4 million registered users who access 160by2.com on internet and mobile to use its services. Apart from being leading websites and WAP site in India, 160by2 users send more than 20 million SMS in a month. Even though the gateway to 160by2 services is through internet, it cleverly sidesteps the problem of low internet penetration in India by providing it services on mobile internet and reaching out to a larger audience through its SMS services.
This leads to a unique integrated advertising media that brands can use to target consumers on internet, WAP and SMS. With its reach of more than 5 million unique mobile phones in India, 160by2 offers highly targeted and interactive means of advertising to its clients. With large majority of users being in age group of 16-34, 160by2 is an ideal medium for brands trying to reach out to the youth who is an opinion leader. 160by2 allows its advertisers to devise campaigns with multiple modes of interaction - on internet, wap and SMS. The call to action to the target audience may be a click to know more (internet/mobile), click to call (mobile), click to SMS (mobile) or click to download (internet/mobile). The advertisers have been using 160by2 medium for targeting consumers by age group, location or gender. 160by2 also allows contextual advertising by placing ads within SMS based on the content of the SMS.

Bangalore blasts and cowards as terrorists

Cowards call themselves Terrorists. Whatever the message, whatever the impression, Bangalore is not a soft or hard target. The idea to stop the Bangalore progress wont be successful. Bangalore will get back to work. How long can the cowards get away? I have faith the cowards will be caught.
Some interesting things that came to my mind
a) The blasts occured near scarp yards near bus routes or bus stops. These are not peak hour traffic times for buses. i travel by buses, even today after blasts I travelled by bus, so the people who did this seem to me have no idea about bus peak times.
b) Some blasts were near or across petrol pumps. ex- Madivala and Vittal Mallya. I dont buy the idea that the terrorists wanted to send a message softly. They wanted maximum damage and luckily none of the petrol pumps were affected.
c) The places are traffic key areas. The idea was to jam the bus routes of IT crowd heading out to homes after friday and their home towns. You can see the blue line in the south part of image below which was the principal target. That is the arterial Hosur road . the terrorists were defeated


d) The principal ares of blast were the Hosur road and Mysore road
As per http://www.forbes.com/afxnewslimited/feeds/afx/2008/07/25/afx5253941.html

"Police said the blasts were of low-intensity but enough to create panic in the city. Police were seen investigating the blast sites to determine the chemicals used.
'Most of the blasts took place between 1:30 pm and 1:45 pm,' Bangalore police commissioner Shankar M Bidari said at one of the blast sites.
The injured have been admitted to the Vittal Mallya Hospital, near which one of the bomb blasts took place.
Noone has claimed responsibility for the bombs, but city police said the blasts bore the hallmark of a terrorist attack.
'We are investigating and will quickly book those involved in the blast,' Bidari said."

"The bombs exploded in arterial roads in Madiwala, Nayandahalli, Adugodi, Rajaram Mohan Roy Circle and Sarjapur." All these are connected to Hosur road as shown below.



Nayandahalli is only exception in the image below not connected to Hosur road. It is connected to Hosur road . It is linked to Mysore road



Categorically the coward terrorists have failed. Bangalore is a dream, you cant kill dreams by panic, fear, murders and blasts. Here I am fighting back using my tool. The pen, the web blog.
Pen is mighthier than sword.

Biocyc: Database of Genome databases:

To illustrate the power of genome database netowrk, you need to have a look at biocyc page.
BioCyc is a collection of 371 Pathway/Genome Databases. Each database in the BioCyc collection describes the genome and metabolic pathways of a single organism.
http://biocyc.org/
BioCyc Pathway/Genome DatabasesThe BioCyc databases are divided into three tiers, based on their quality.
Tier 2 and Tier 3 databases contain computationally predicted metabolic pathways, predictions as to which genes code for missing enzymes in metabolic pathways, and predicted operons.

BioCyc Tier 1: Intensively Curated Databases




Database

Scope

Highlights


EcoCyc

Escherichia coli K-12 Model-Organism Database

Literature curation of complete genomeInformation from 17,000 publicationsTranscriptional regulatory networkProtein complexesEnzyme and transporter functionsGene Ontology assignments

MetaCyc

Multiorganism Metabolic Pathway and Enzyme Database

1,100 metabolic pathwaysPathways elucidated from 1,500 organismsExtensive commentary and references


The BioCyc Open Chemical Database is an open database of chemical compounds from other BioCyc databases. Because it contains chemical compounds only, it is not a Pathway/Genome Database.
The comparison of Urea cycle: pathway is possible between Homo Sapiens and E. coli O157:H7 EDL933 Pathway: urea cycle.


I did a cross species comparison between the two for a pathway, and I could choose any genome database


E. coli O157:H7 EDL933 Pathway: urea cycle



Homo Sapiens: Urea cycle pathway


The genes/enymes for Homosapiens
EC# 6.3.4.16
carbamoyl-phosphate synthase (ammonia), mitochondrial precursor: CPS1
EC# 2.1.3.3
ornithine carbamoyltransferase, mitochondrial precursor: OTC
EC# 6.3.4.5
argininosuccinate synthase: ENSG00000165232 argininosuccinate synthase: ENSG00000139130 argininosuccinate synthase: ENSG00000179595 argininosuccinate synthase: ASS argininosuccinate synthase: ENSG00000128605 argininosuccinate synthase: ENSG00000180191 argininosuccinate synthase: ENSG00000176192
EC# 4.3.2.1
argininosuccinate lyase: ENSG00000099934 argininosuccinate lyase: ASL
EC# 3.5.3.1
arginase II, mitochondrial precursor: ARG2 arginase 1: ARG1
The genes/enymes for Ecoli

EC# 6.3.4.16
None
EC# 2.1.3.3
ornithine carbamoyltransferase 1: argI
EC# 6.3.4.5
argininosuccinate synthetase: argG
EC# 4.3.2.1
argininosuccinate lyase: argH
EC# 3.5.3.1
None

There is a visible similarity between the two organisims and their functions for this pathway.

RedBUS.IN

Know your best buy in redbus.in
A search in redbus.in gives you the dynamics of bus rates clearly.


I searched a query from Bangalore to Belgaum

Travels Bus Type Departure Arrival Fare(Rs) Seats

VRL Travels 2+2 Executive 7:30 PM 6:45 AM 378 31

S.S.Travels Blr 2+1 Non A/C Sleeper 8:15 PM 7:00 AM 380 4

S.S.Travels Blr 2+1 Non A/C Sleeper 9:45 PM 8:00 AM 400 4

Sugama Tourist 2+1 Seater & Sleeper 8:00 PM 7:30 AM 400 -

S.R.S Travels CHNI AirSuspention VCD Coach 8:00 PM 5:30 AM 330 -

Sugama Tourist 2+1 Seater & Sleeper 10:00 PM 7:30 AM 400 -


Interesting to note I can get a 70/330 = 21% profit if I plan to go by SRS Travels. In addition, I can get a redbus executive to confirm my ticket. Plus I can print my ticket. No wonder Redbus is catching on.




3) The hassle of choosing the bus is now with the end user. Plus he can see the pickup points as well


4) How the Redbus model works is explained in the blog and why it has groen to 1000 customers quickly. Why does it attract the IIM-B crowd.


Thursday, July 24, 2008

Good python read

http://www.ibiblio.org/swaroopch/byteofpython/files/120/byteofpython_120.pdf 12-Jan-2005 17:50 337K
http://www.ibiblio.org/swaroopch/byteofpython/files/120/byteofpython_120.txt12-Jan-2005 17:51 201K
http://www.ibiblio.org/swaroopch/byteofpython/files/120/byteofpython_fullsource_120.tar.gz12-Jan-2005 20:04 13M
http://www.ibiblio.org/swaroopch/byteofpython/files/120/byteofpython_html_120.zip 12-Jan-2005 17:51 266K
http://www.ibiblio.org/swaroopch/byteofpython/files/120/byteofpython_html_single_120.zip 12-Jan-2005 17:52 136K
http://www.ibiblio.org/swaroopch/byteofpython/files/120/byteofpython_source_120.tar.gz 12-Jan-2005 17:52 136K

Sameer Guglani starts Morpheus Ventures On YCombinator model

With 4-8% equity, the Morpheus ventures http://www.morpheusventure.com/ promises to the ideal bet for entrepreneurs in iNdIa
sameer@morpheusventure.com
mailto:nandini@morpheusventure.com

A morpheus application form looks like below to be mailed to mailto:neo@morpheusventure.com.
http://www.morpheusventure.com/startupinfo/MVP_ApplicationForm.doc
morpheus venture partners – Application Form
Application Deadline:
1. Please provide as much information as possible for us to understand you and your project better and assess you rightly.
2. We will not let anyone outside of morpheus look at this application form, including other startups we work with
3. Even if you have a good product that’s live or a great demo, we suggest you provide as much information in this application as we look at the live product / demo based on information in this application.

email this application to: neo@morpheusventure.com


1
Company Info:
a
Name
b
Company URL (if any)
c
Phone number(s)
d
Address(es)
2
What product or service does your company make?


3
Founding team information (Provide all details for each founder, list the main founder first)
a
Name, age, email address, personal url (if any)

b
Current employer and title OR Current college and name of degree (as applicable)
c
Provide details for each college separately:
· Name of college attended
· Year of graduation
· Subject of each degree
d
Provide details for each company separately:
· Name of company worked at and title
· Month, year of joining and leaving
· Roles played at the company
4
Details about the venture/idea; how, when, where, why was the venture/idea started? Basically, the story behind the venture.


5
What is the problem your venture is solving or trying to solve? Provide an example by describing a typical user who is facing this problem.


6
What is the current status of the venture / business?
a
Status of product (alpha, beta, idea-stage)
b
Lines of code written (if applicable)
c
Revenues (if any)
d
Monthly burn rate
e
Current investments and at what valuations
(Self funded, Friends, Family, Angel, etc.)
f
Current shareholding structure
7
What are you looking to achieve / accomplish in the next 6 months?


8
If you have an online demo, what's the url? (Please provide details of username/ password/ promo codes/ invites etc.)


9
Tell us in one or two sentences about something impressive that each founder has achieved / built/ done


10
Talk about an interesting project, preferably outside of college or work that two or more of you have work on / created together. Include URLs if possible.


11
How long have the team known one another and how did you meet?


12
What is it about your business that is missing from existing solutions/products?


13
Who are your direct and indirect competitors? Who do you think will be most dangerous?


14
How will you make money?


15
Please tell us something surprising or interesting that one of you has discovered. (The answer need not be related to your venture/idea)


16
How long will it take for you to have a beta version? A paid version?


17
If morpheus selects you as one of the companies to work with, which of the founders will commit to working exclusively on this project for the next one year (this means no studies, other jobs or other projects)?


18
Do any of the founders have other commitments between Sep and Dec 2008 inclusive?


19
Are any of the following true? Indicate Yes beside the options that are applicable
a
You are the ONLY founder

b
One or more founders will keep their current jobs

c
None of the founders are programmers

20
What do you expect from Morpheus?



Apply http://www.morpheusventure.com/apply.html
morpheus is now accepting applications for the second batch of 2008. It will take place September through December 2008.
To apply, please download the
application form , fill up all the information and e-mail it to neo@morpheusventure.com . Last date for submission is 5 August 2008. Teams that submit early have an advantage because we have more time to read the applications.
We'll review applications as they come in and set-up a 2 weeks interaction with shortlisted companies. This will also include face-to-face interaction.
We'll select 5 companies to work with by August 20 , and will also decide the amount of equity we will take. Equity will be between 4% and 8% of the company. The median will be 6%.
Once we communicate our offer to you, your team will have ONE day to make the decision to accept or decline the offer.
morpheus is not an incubator. We have some space you can use if you need to, but we expect you to work out of your office/appartment/garage. It's the ideal setup for the initial phase.
We have built a panel of Subject matter experts with varied expertise and experiences, who will be available to work with the morpheus companies either on a one-off basis or for a longer advisory role, with specific timelines/deliverables built in.
During the 2 weeks evaluation period, morpheus will engage in detailed discussions about the strategy, vision of the team, the product that will be / is getting built, product roadmap, timelines and the market potential.
During the discussion period, morpheus expects that you evaluate the morpheus team, the value they bring to the table, the fit between your team and morpheus and send out any questions/ queries/concerns that you may have. Note: We strongly encourage you to talk to Founders of other companies we have closely worked with. We will be happy to share their contact information with you.
There is absolutely no monitory fee that morpheus charges from the startups it works with. We are willing to wait, the long haul, for 4-7 years – the timeframe a startup may need to reach exit point.
morpheus does not invest money in ventures at this point in time.
We encourage you to ask the founders of other morpheus companies for help. There will be about 20 of them starting September, and they're usually very willing to give advice or make introductions.
About 3.5 months into the program morpheus will organize an one day event where you can present to investors. You can of course seek additional funding from any investor whenever you want.
morpheus program doesn't end after four months. We will continue to provide advice and make introductions as long as founders need and so does the informal network of morpheus companies.
How do we choose who to work with? The people in your team are the most important aspect. We look for intelligence, passion, motivation, a sense of design and the attitude where teams refuse to fail.
The ideal company would have two or three founders. We'll consider those with four or five.
You dont need to have a formal business plan. Just fill the application form with sufficient information.
The original motivation to start morpheus was to work with startups and provide required advice, introductions, etc. but this is not a charity. If startups we work with become successful we will be able to work with more startups in coming months, if they dont, we wont be able to keep doing this indefinately. So we are looking for startups that will be successful.
© 2008 morpheus venture partners


http://www.contentsutra.com/entry/419-morpheus-ventures-on-their-funding-model/
Sameer Guglani and Nandini Hirianniah recently announced the launch of their Y-Combinator modeled Morpheus Ventures. Guglani had sold Madhouse for an undisclosed sum to SeventyMM around the same time last year. More on their funding model in the interview below:
CS: Are you completely out of Madhouse and SeventyMM now? SG: Morpheus has been started by two partners: myself and Nandini Hirianniah. Both were us also founders of madhouse, so we have worked together as a team before. Nandini left seventymm a couple of months back and my last day as a Seventymm employee will be 31 July. Both us will be working full time on morpheus venture partners CS: Are you going to relegate Morpheus to start-ups or build it into a more generic web consultancy? SG: Morpheus will be be focused only on early stage startups, our goal is to work with teams who are 0-12 months old or may be even at the idea stage. Teams who can build scalable and fundable businesses
CS: Why the YCombinator model as opposed to an Angel or Seedfund? SG: Because thats where we believe the gap is most wide. Today there is enough supply of capable entrepreneurs, folks who are taking the plunge - quiting their jobs, putting together a team, building prototypes and dreaming to build a big business. At the same time the supply of money to be invested in startups is also quite enough. Many VC funds, seed stage funds and plenty of angels. These guys are happy to consider investing in companies who are at the right stage, with the right team and the right model. So we add value to both the parties i.e. the entrepreneur and the startup investors using the morpheus/Ycombinator model. For about 4-6 months we work closely with the founders to build the right product, getting the right team, getting initial customer traction and have something impressive ready which will allow them to raise professional funding. To investors our value add is that we are helping in building high quality fundable startups,we will also be conducting demo events where all our portfolio companies will demo their products and the investors can interact with bunch of high quality startups.
CS: What value does Morpheus Venture bring to a start-up? SG: For about 4-6 months we work closely with the founders to build the right product, getting the right team, getting initial customer traction and have something impressive ready which will allow them to raise professional funding. We make introductions to potential investors, partners, lawyers, accountants, domain experts. These are only few main things, the real collaboration will include many more things, needs of each startup are unique and we will adapt to them.
CS: What is the average equity you look at obtaining? SG: Morpheus will be looking at taking 4-8% equity, there is absolutely no monitory fee that we charge. We are in for the long haul and willing to wait for 4-7 years, which a startup may need to each the exit point. CS: What is the average exit period Morpheus is looking at? SG: I would say average would be 5 years, assuming the M&A market continues to develop.
CS: Can you share some start-ups and their products with whom you have been working off late? SG: “We currently have three portfolio companies, two of whom have already raised venture funding



http://ycombinator.com/about.html
What We Do
Y Combinator does seed funding for startups. Seed funding is the earliest stage of venture funding. It pays your expenses while you're getting started.
Some companies may need no more than seed funding. Others will go through several rounds. There is no right answer; how much funding you need depends on the kind of company you start.
At Y Combinator, our goal is to get you through the first phase. This usually means: get you to the point where you've built something impressive enough to raise money on a larger scale. Then we introduce you to later stage investors—and in some cases even acquirers.
More Than Money
We make small investments (rarely more than $20,000) in return for small stakes in the companies we fund (usually 2-10%).
All venture investors supply some combination of money and help. In our case the money is by far the smaller component. In fact, many of the startups we fund don't need the money. We think of the money we invest as more like financial aid in college: it's so people who do need the money can pay their living expenses while Y Combinator is happening.
What happens at Y Combinator? The most important thing we do is work with startups on their ideas. We're hackers ourselves, and we've spent a lot of time figuring out how to make things people want. So we can usually see fairly quickly the direction in which a small idea should be expanded, or the point at which to begin attacking a large but vague one.
The questions at this stage range from apparently minor (what to call the company) to frighteningly ambitious (the long-term plan for world domination). Over the course of three months we usually manage to help founders come up with initial answers to all of them.
Though we fund all types of computer startups, we're especially interested in web-based applications. We've been thinking about that problem longer than anyone else, and by now can visualize much of the space of possibilities.
The second most important thing we do is help founders deal with investors and acquirers. Yes, we make introductions, but that part is easy. We spend much more time teaching founders how to pitch their startups, and how to close a deal once they've generated interest. In the second phase we supply not just advice but protection; people are more likely to treat you well if you come from YC, because how they treat you determines whether in the future we'll steer deals toward or away from them.
We also get the startups we fund incorporated properly with all the right paperwork, avoiding legal time-bombs that could kill them later. We introduce founders to lawyers who will often, because of the YC connection, agree to defer payment for legal work. We regularly help startups find and hire their first employees. We advise about what to patent, and when. One of the least publicized things we do, for obvious reasons, is mediate disputes between founders. No startup thinks they're going to need that, but most do at some point.
The kind of advice we give literally can't be bought, because anyone qualified to give it is already rich. You can only get it from investors.
Format
Y Combinator has a novel approach to seed funding: we fund startups in batches. There are two each year, one in the summer in Cambridge, and one in the winter in Mountain View. During each cycle we fund multiple startups. We've funded a total of 102 so far.
Applying for funding is also different at Y Combinator. Instead of submitting a business plan or making a slide presentation, you just fill out an application form. We invite the most promising groups to meet us in person, and we make funding decisions immediately afterward.
Most of the founders in each startup we fund are expected to move to our location for at least three months: the Bay Area January through March for startups in the winter cycle, and Cambridge June through August for summer ones.
During those three months we host a dinner once a week at Y Combinator, and at each dinner we invite an expert in some aspect of startups to speak. Typically speakers include startup founders, venture capitalists, lawyers, accountants, journalists, investment bankers, and executives from big technology companies.
About ten weeks in, we host an investor day where all the startups can present to potential investors. Ten weeks turns out to be enough for most groups to create a convincing prototype. In fact, many launch in less than ten weeks.
Y Combinator is sometimes described as a boot camp, but this is not really accurate. We probably get called that because we fund a lot of startups at once, and most have to move to participate. But the similarities end there; the atmosphere is the opposite of regimented.
Funding startups in batches works better for everyone than the usual approach. It's more efficient for us, but also better for the startups, who probably end up helping one another at least as much as we help them.
Because we fund such large numbers of startups, Y Combinator has a huge "alumni" network, and there's a strong ethos of helping out fellow YC founders. So whatever your problem, whether you need beta testers, a place to stay in another city, advice about a browser bug, or a connection to a particular company, there's a good chance someone in the network can help you.
Philosophy
We think hackers are most productive when they can spend most of their time hacking. Our goal is to create an environment where you can focus exclusively on getting an initial version built. In any startup, the first couple months tend to be the most productive of all. Those first months define the company. So anything you can do to maximize their effects is probably a good idea.
We seem to have succeeded in creating a good environment, because many founders have told us that the first ten weeks of Y Combinator were the most productive period of their lives.
We try to interfere as little as possible in the startups we fund. We don't want board seats, rights to participate in future rounds, vetoes over strategic decisions, or any of the other powers investors sometimes require. We offer lots of advice, but we can't force anyone to take it. We realize that independence is one of the reasons people want to start startups in the first place. And frankly, it's also one of the reasons startups succeed. Investors who try to control the companies they fund often end up destroying them.
One concrete consequence is that Y Combinator funding lets you sell early, if you want to. It can sometimes make sense to sell yourself when you're small for a few million, rather than take more funding and roll the dice again. Google likes to do early-stage acquisitions, and we expect them to become increasingly common as other companies learn what Google has.
If you take a large amount of money from an investor, you usually give up this option. But we realize (having been there) that an early offer from an acquirer can be very tempting for a group of young hackers. So if you want to sell early, that's ok. We'd make more if you went for an IPO, but we're not going to force anyone to do anything they don't want to.
Why are we so flexible? Not (just) because we're nice people. We realize that, as it gets cheaper to start a company, the balance of power is shifting from investors to hackers. We think the way of the future is simply to offer hackers the best possible deal.
Our goal is to be the preferred source of seed funding, and to be that we have to do right by everyone. The good hackers all know one another, so if the groups we fund feel they're getting a bad deal, no one will want funding from us in the future. And later stage investors (especially VCs) also tend to know one another, so if the companies we seed end up being broken in any way, no one will want to invest in them in the future.
So far we seem to be on track, because both the startups we've funded and their next round of investors seem happy with us.

What We Do
Y Combinator does seed funding for startups. Seed funding is the earliest stage of venture funding. It pays your expenses while you're getting started.
Some companies may need no more than seed funding. Others will go through several rounds. There is no right answer; how much funding you need depends on the kind of company you start.
At Y Combinator, our goal is to get you through the first phase. This usually means: get you to the point where you've built something impressive enough to raise money on a larger scale. Then we introduce you to later stage investors—and in some cases even acquirers.
More Than Money
We make small investments (rarely more than $20,000) in return for small stakes in the companies we fund (usually 2-10%).
All venture investors supply some combination of money and help. In our case the money is by far the smaller component. In fact, many of the startups we fund don't need the money. We think of the money we invest as more like financial aid in college: it's so people who do need the money can pay their living expenses while Y Combinator is happening.
What happens at Y Combinator? The most important thing we do is work with startups on their ideas. We're hackers ourselves, and we've spent a lot of time figuring out how to make things people want. So we can usually see fairly quickly the direction in which a small idea should be expanded, or the point at which to begin attacking a large but vague one.
The questions at this stage range from apparently minor (what to call the company) to frighteningly ambitious (the long-term plan for world domination). Over the course of three months we usually manage to help founders come up with initial answers to all of them.
Though we fund all types of computer startups, we're especially interested in web-based applications. We've been thinking about that problem longer than anyone else, and by now can visualize much of the space of possibilities.
The second most important thing we do is help founders deal with investors and acquirers. Yes, we make introductions, but that part is easy. We spend much more time teaching founders how to pitch their startups, and how to close a deal once they've generated interest. In the second phase we supply not just advice but protection; people are more likely to treat you well if you come from YC, because how they treat you determines whether in the future we'll steer deals toward or away from them.
We also get the startups we fund incorporated properly with all the right paperwork, avoiding legal time-bombs that could kill them later. We introduce founders to lawyers who will often, because of the YC connection, agree to defer payment for legal work. We regularly help startups find and hire their first employees. We advise about what to patent, and when. One of the least publicized things we do, for obvious reasons, is mediate disputes between founders. No startup thinks they're going to need that, but most do at some point.
The kind of advice we give literally can't be bought, because anyone qualified to give it is already rich. You can only get it from investors.
Format
Y Combinator has a novel approach to seed funding: we fund startups in batches. There are two each year, one in the summer in Cambridge, and one in the winter in Mountain View. During each cycle we fund multiple startups. We've funded a total of 102 so far.
Applying for funding is also different at Y Combinator. Instead of submitting a business plan or making a slide presentation, you just fill out an application form. We invite the most promising groups to meet us in person, and we make funding decisions immediately afterward.
Most of the founders in each startup we fund are expected to move to our location for at least three months: the Bay Area January through March for startups in the winter cycle, and Cambridge June through August for summer ones.
During those three months we host a dinner once a week at Y Combinator, and at each dinner we invite an expert in some aspect of startups to speak. Typically speakers include startup founders, venture capitalists, lawyers, accountants, journalists, investment bankers, and executives from big technology companies.
About ten weeks in, we host an investor day where all the startups can present to potential investors. Ten weeks turns out to be enough for most groups to create a convincing prototype. In fact, many launch in less than ten weeks.
Y Combinator is sometimes described as a boot camp, but this is not really accurate. We probably get called that because we fund a lot of startups at once, and most have to move to participate. But the similarities end there; the atmosphere is the opposite of regimented.
Funding startups in batches works better for everyone than the usual approach. It's more efficient for us, but also better for the startups, who probably end up helping one another at least as much as we help them.
Because we fund such large numbers of startups, Y Combinator has a huge "alumni" network, and there's a strong ethos of helping out fellow YC founders. So whatever your problem, whether you need beta testers, a place to stay in another city, advice about a browser bug, or a connection to a particular company, there's a good chance someone in the network can help you.
Philosophy
We think hackers are most productive when they can spend most of their time hacking. Our goal is to create an environment where you can focus exclusively on getting an initial version built. In any startup, the first couple months tend to be the most productive of all. Those first months define the company. So anything you can do to maximize their effects is probably a good idea.
We seem to have succeeded in creating a good environment, because many founders have told us that the first ten weeks of Y Combinator were the most productive period of their lives.
We try to interfere as little as possible in the startups we fund. We don't want board seats, rights to participate in future rounds, vetoes over strategic decisions, or any of the other powers investors sometimes require. We offer lots of advice, but we can't force anyone to take it. We realize that independence is one of the reasons people want to start startups in the first place. And frankly, it's also one of the reasons startups succeed. Investors who try to control the companies they fund often end up destroying them.
One concrete consequence is that Y Combinator funding lets you sell early, if you want to. It can sometimes make sense to sell yourself when you're small for a few million, rather than take more funding and roll the dice again. Google likes to do early-stage acquisitions, and we expect them to become increasingly common as other companies learn what Google has.
If you take a large amount of money from an investor, you usually give up this option. But we realize (having been there) that an early offer from an acquirer can be very tempting for a group of young hackers. So if you want to sell early, that's ok. We'd make more if you went for an IPO, but we're not going to force anyone to do anything they don't want to.
Why are we so flexible? Not (just) because we're nice people. We realize that, as it gets cheaper to start a company, the balance of power is shifting from investors to hackers. We think the way of the future is simply to offer hackers the best possible deal.
Our goal is to be the preferred source of seed funding, and to be that we have to do right by everyone. The good hackers all know one another, so if the groups we fund feel they're getting a bad deal, no one will want funding from us in the future. And later stage investors (especially VCs) also tend to know one another, so if the companies we seed end up being broken in any way, no one will want to invest in them in the future.
So far we seem to be on track, because both the startups we've funded and their next round of investors seem happy with us.
What We Do
Y Combinator does seed funding for startups. Seed funding is the earliest stage of venture funding. It pays your expenses while you're getting started.
Some companies may need no more than seed funding. Others will go through several rounds. There is no right answer; how much funding you need depends on the kind of company you start.
At Y Combinator, our goal is to get you through the first phase. This usually means: get you to the point where you've built something impressive enough to raise money on a larger scale. Then we introduce you to later stage investors—and in some cases even acquirers.
More Than Money
We make small investments (rarely more than $20,000) in return for small stakes in the companies we fund (usually 2-10%).
All venture investors supply some combination of money and help. In our case the money is by far the smaller component. In fact, many of the startups we fund don't need the money. We think of the money we invest as more like financial aid in college: it's so people who do need the money can pay their living expenses while Y Combinator is happening.
What happens at Y Combinator? The most important thing we do is work with startups on their ideas. We're hackers ourselves, and we've spent a lot of time figuring out how to make things people want. So we can usually see fairly quickly the direction in which a small idea should be expanded, or the point at which to begin attacking a large but vague one.
The questions at this stage range from apparently minor (what to call the company) to frighteningly ambitious (the long-term plan for world domination). Over the course of three months we usually manage to help founders come up with initial answers to all of them.
Though we fund all types of computer startups, we're especially interested in web-based applications. We've been thinking about that problem longer than anyone else, and by now can visualize much of the space of possibilities.
The second most important thing we do is help founders deal with investors and acquirers. Yes, we make introductions, but that part is easy. We spend much more time teaching founders how to pitch their startups, and how to close a deal once they've generated interest. In the second phase we supply not just advice but protection; people are more likely to treat you well if you come from YC, because how they treat you determines whether in the future we'll steer deals toward or away from them.
We also get the startups we fund incorporated properly with all the right paperwork, avoiding legal time-bombs that could kill them later. We introduce founders to lawyers who will often, because of the YC connection, agree to defer payment for legal work. We regularly help startups find and hire their first employees. We advise about what to patent, and when. One of the least publicized things we do, for obvious reasons, is mediate disputes between founders. No startup thinks they're going to need that, but most do at some point.
The kind of advice we give literally can't be bought, because anyone qualified to give it is already rich. You can only get it from investors.
Format
Y Combinator has a novel approach to seed funding: we fund startups in batches. There are two each year, one in the summer in Cambridge, and one in the winter in Mountain View. During each cycle we fund multiple startups. We've funded a total of 102 so far.
Applying for funding is also different at Y Combinator. Instead of submitting a business plan or making a slide presentation, you just fill out an application form. We invite the most promising groups to meet us in person, and we make funding decisions immediately afterward.
Most of the founders in each startup we fund are expected to move to our location for at least three months: the Bay Area January through March for startups in the winter cycle, and Cambridge June through August for summer ones.
During those three months we host a dinner once a week at Y Combinator, and at each dinner we invite an expert in some aspect of startups to speak. Typically speakers include startup founders, venture capitalists, lawyers, accountants, journalists, investment bankers, and executives from big technology companies.
About ten weeks in, we host an investor day where all the startups can present to potential investors. Ten weeks turns out to be enough for most groups to create a convincing prototype. In fact, many launch in less than ten weeks.
Y Combinator is sometimes described as a boot camp, but this is not really accurate. We probably get called that because we fund a lot of startups at once, and most have to move to participate. But the similarities end there; the atmosphere is the opposite of regimented.
Funding startups in batches works better for everyone than the usual approach. It's more efficient for us, but also better for the startups, who probably end up helping one another at least as much as we help them.
Because we fund such large numbers of startups, Y Combinator has a huge "alumni" network, and there's a strong ethos of helping out fellow YC founders. So whatever your problem, whether you need beta testers, a place to stay in another city, advice about a browser bug, or a connection to a particular company, there's a good chance someone in the network can help you.
Philosophy
We think hackers are most productive when they can spend most of their time hacking. Our goal is to create an environment where you can focus exclusively on getting an initial version built. In any startup, the first couple months tend to be the most productive of all. Those first months define the company. So anything you can do to maximize their effects is probably a good idea.
We seem to have succeeded in creating a good environment, because many founders have told us that the first ten weeks of Y Combinator were the most productive period of their lives.
We try to interfere as little as possible in the startups we fund. We don't want board seats, rights to participate in future rounds, vetoes over strategic decisions, or any of the other powers investors sometimes require. We offer lots of advice, but we can't force anyone to take it. We realize that independence is one of the reasons people want to start startups in the first place. And frankly, it's also one of the reasons startups succeed. Investors who try to control the companies they fund often end up destroying them.
One concrete consequence is that Y Combinator funding lets you sell early, if you want to. It can sometimes make sense to sell yourself when you're small for a few million, rather than take more funding and roll the dice again. Google likes to do early-stage acquisitions, and we expect them to become increasingly common as other companies learn what Google has.
If you take a large amount of money from an investor, you usually give up this option. But we realize (having been there) that an early offer from an acquirer can be very tempting for a group of young hackers. So if you want to sell early, that's ok. We'd make more if you went for an IPO, but we're not going to force anyone to do anything they don't want to.
Why are we so flexible? Not (just) because we're nice people. We realize that, as it gets cheaper to start a company, the balance of power is shifting from investors to hackers. We think the way of the future is simply to offer hackers the best possible deal.
Our goal is to be the preferred source of seed funding, and to be that we have to do right by everyone. The good hackers all know one another, so if the groups we fund feel they're getting a bad deal, no one will want funding from us in the future. And later stage investors (especially VCs) also tend to know one another, so if the companies we seed end up being broken in any way, no one will want to invest in them in the future.
So far we seem to be on track, because both the startups we've funded and their next round of investors seem happy with us.